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Tablet Coating

Tablet Coating

This video provides a functional overview of  the tablet coating process used in oral solid dose manufacturing including a special emphasis on the critical-to-quality elements of film coating in a drum coater.

Used by Drug Makers, Equipment Manufacturers, College and University Professors, Technical Schools, Training Consultants, Operating Personnel, Maintenance Personnel, Field Service Professionals, and Industry Regulators.

Narrative Excerpts

"...the coating process, strict sampling criteria are followed to measure tablet weight and visual quality throughout the run until the target weight is achieved. Common appearance issues can be resolved through small adjustments of the coating process variables during the coating process..."

"...one common issue, Tablet-to-Tablet Color Variation or Shading, occurs when the tablets receive an insufficient amount of coating to achieve uniform coverage. To resolve “Shading”, first verify that the spray gun angle and distance are correct and then slowly increase the pan speed to increase the number of times the tablet cores will travel under the spray guns. Once the pan speed has been increased, decrease the spray rate to rebalance the process. The time to get to the target weight will increase, but shading will be resolved..."

"...another issue, chipping, can occur if a tablet lacks robustness or the process is too aggressive causing the tablet cores to chip as they tumble against one another. To reduce or eliminate coating chips, an operator can decrease the pan speed or increase the spray rate. Chipping can also be a sign of sharp edges on tablets which are created from the use of worn tablet punches or inherent low tablet hardness / friability..."

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