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Tablet Compression

Tablet Compression

This video provides a functional overview of the tablet compression process used in oral solid dose manufacturing with a special emphasis on the critical-to-quality elements within the primary stages of tablet making:  The Filling Stage, The Metering Stage, The Compression Stage and The Ejection Stage.

Used by Drug Makers, Equipment Manufacturers, College and University Professors, Technical Schools, Training Consultants, Operating Personnel, Maintenance Personnel, Field Service Professionals, and Industry Regulators.

Narrative Excerpts

"...the Compression Stage, the upper and lower punches travel between two pairs of large wheels called pressure rolls. The upper rolls are referred to as the Pre and Final Penetration Rolls.  The lower rolls are referred to as the Pre and Main or Final Compression Rolls.The first pair of rolls gently forces the punches together in the die to remove excess air from the granulation. Removal of air is important as it could expand during the tablet ejection phase from the tablet press, resulting in capping or laminated tablets. Pre-compression also helps form a stronger tablet by increasing dwell time..."

"...the second pair forces the punches closer together in the die hard enough to form a tablet. The distance between the upper and lower punches determines two things; the thickness of the tablet produced and its porosity. These in turn will determine how hard the tablet is and its disintegration time. As discussed in a previous module, particles either compress mainly by brittle fracture or by deformation. Fragmentation only requires force to be applied; deformation requires both force and time, hence dwell time during compression becomes a critical process parameter. Particles that compress mainly by deformation are susceptible to over-mixing with Magnesium Stearate as it is able to cover all the faces of the particles, hence the requirement for short mixing times..."

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